Cyclin-dependent kinases as cellular targets for antiviral drugs

Cyclin-Dependent Kinases (Cdk) as Targets for Cancer Therapy and Imaging

Aberration in proliferation and consequently in cell cycle control is a common aspect in carcinogenesis. As master cell cycle regulating proteins in all eukaryotic cells the Cyclindependent kinases (Cdk) were identified by Leland Hartwell, Paul Nurse, and Timothy Hunt in the 1970s and 1980s. Chronological activation of respective Cdk according to respective cell cycle phase G1, S, G2 or M is me...

Mammalian cyclin-dependent kinases.

Cyclin-dependent kinases (Cdks) are the catalytic subunits of a family of mammalian heterodimeric serine/threonine kinases that have been implicated in the control of cell-cycle progression, transcription and neuronal function. Recent genetic evidence obtained with gene-targeted mice has shown that Cdk4 and Cdk6 are not needed for entry into the cell cycle after mitogenic stimuli and organogene...

Cyclin-dependent kinases as a therapeutic target for stroke.

Cyclin-dependent kinases (CDKs) are commonly known to regulate cell proliferation. However, previous reports suggest that in cultured postmitotic neurons, activation of CDKs is a signal for death rather than cell division. We determined whether CDK activation occurs in mature adult neurons during focal stroke in vivo and whether this signal was required for neuronal death after reperfusion inju...

Early G1 cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma

Early G₁ cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma.

PURPOSE Chromosomal gain at 7q21 is a frequent event in esophageal adenocarcinoma (EAC). However, this event has not been mapped with fine resolution in a large EAC cohort, and its association with clinical endpoints and functional relevance are unclear. EXPERIMENTAL DESIGN We used a cohort of 116 patients to fine map the 7q21 amplification using SNP microarrays. Prognostic significance and f...